Marika Pečená was born in Prague, and combined university studies in medicine with musicology. She started conducting in mid nineties. In 1996-98 she acted as assistant choirmaster in Bach - Collegium Prague under Vladimír Novák. In 1999 she formed ensemble Collegium 419 with which she performed early music including revival-premieres from period manuscripts. She was engaged in Collegium 419 until September 2007.
She is member of the Board of the Czech Sacred Music Society (SDH), where she organizes International Summer school of Sacred Music Convivium (2004, 2005, 2011, 2014) in Premonstratensian monastery Želiv. 

Marika Pečená privately studied piano with Marie Magdalena Horňanová and choral conducting with Čestmír Stašek and Marek Štryncl. With Collegium 419 she the cycle of cantatas Membra Jesu Nostri by Dietrich Buxtehude, Israelis Brünnlein by Johann Hermann Schein, Historia der Auferstehung by Heinrich Schütz and others. In September 2005, she realized with Collegium 419 revival-premiere of Responsories by Jakub Jan Ryba (Czech late-18th century composer) at  St. Wenceslas Festivities International Festival of Sacred Arts.

In March 2010 she realized with ensemble Sursum Corda Musicalische Exequien by Heinrich Schütz at the Sacred Music Cycle Lenten Fridays in Prague.

Since  2010 she co-operates with Premonstratensian monastery Želiv as an Artistic Director of the newly founded festival Zeliv Culture Summer - Musica Figurata Zeliv. Since 2010 she also organizes Sacred Music Cycle Lenten Fridays in Prague.

Marika Pečená graduated at Charles University in Prague - 2nd Faculty of Medicine and is employed as a drug development professional in pharmaceutical industry.